Neurodevelopment of Episodic Memory in Children with Type 1 Diabetes
Recent evidence demonstrates that DKA is associated with changes in cerebral water distribution, cerebral blood flow and cerebral metabolism which are similar to those often observed with mild hypoxic/ischemic in the brain. Given known susceptibility of the hippocampal formation to hypoxia and ischemia and known role of the hippocampus in episodic memory, we are currently examining changes in hippocampal structure and function associated with DKA and T1DM.
The long-term goal of this research program is to document the developmental trajectory of memory functioning in diverse populations, including but not limited to individuals with T1DM. The findings from this research will inform intervention programs for atypical development and also provide a window into the mechanisms of typical development. This research has significant implications for the treatment of T1DM in children and can potentially contribute to our understanding of how metabolic insults affect the developing brain, and memory function.